Circadian rhythms in solid organ transplantation

Circadian rhythms are daily cycles in physiology that can affect medical interventions. This review considers how these rhythms may relate to solid organ transplantation. It begins by summarizing the mechanism for circadian rhythm generation known as the molecular clock, and basic research connectin...

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Bibliographic Details
Published inThe Journal of heart and lung transplantation Vol. 43; no. 5; pp. 849 - 857
Main Authors Patlin, Brielle H., Mok, Huram, Arra, Monaj, Haspel, Jeffrey A.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.05.2024
Subjects
chronophamacology
circadian rhythms
immunity
ischemia
molecular clock
time of day
transplantation
molecular clock
transplantation
chronophamacology
immunity
circadian rhythms
time of day
ischemia
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Summary:Circadian rhythms are daily cycles in physiology that can affect medical interventions. This review considers how these rhythms may relate to solid organ transplantation. It begins by summarizing the mechanism for circadian rhythm generation known as the molecular clock, and basic research connecting the clock to biological activities germane to organ acceptance. Next follows a review of clinical evidence relating time of day to adverse transplantation outcomes. The concluding section discusses knowledge gaps and practical areas where applying circadian biology might improve transplantation success.
Bibliography:ObjectType-Article-1
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ISSN:1053-2498
1557-3117
DOI:10.1016/j.healun.2024.01.017