The role of phosphoenolpyruvate in insulin secretion: the effect of L-phenylalanine

Incubation of rat islets with phenylalanine increased the tissue content of phosophoenolpyruvate, both in the presence and in the absence of glucose. At the same time, L-phenylalanine neither stimulated nor inhibited insulin release. It is unlikely that insulin secretion is tightly coupled to the av...

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Bibliographic Details
Published inExperientia Vol. 40; no. 12; p. 1426
Main Authors Chatterton, T A, Reynolds, C H, Lazarus, N R, Pogson, C I
Format Journal Article
LanguageEnglish
Published Switzerland 15.12.1984
Subjects
Alanine - pharmacology
Animals
Glucose - pharmacology
Insulin - metabolism
Insulin Secretion
Islets of Langerhans - drug effects
Islets of Langerhans - metabolism
Male
Phenylalanine - pharmacology
Phosphoenolpyruvate - physiology
Rats
Rats, Inbred Strains
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Summary:Incubation of rat islets with phenylalanine increased the tissue content of phosophoenolpyruvate, both in the presence and in the absence of glucose. At the same time, L-phenylalanine neither stimulated nor inhibited insulin release. It is unlikely that insulin secretion is tightly coupled to the availability of phosphoenolpyruvate in rat islets.
ISSN:0014-4754
DOI:10.1007/BF01951926