Successful wheat-specific oral immunotherapy in highly sensitive individuals with a novel multirush/maintenance regimen

We reported a successful oral immunotherapy (OIT) in 2 children with high wheat sensitivity (4 and 14 years old boys). Oral challenges indicated eliciting doses of 300 mg, and wheat flour of 30 mg. The OIT protocol includes 5 days of build-up phase in the hospital, intervening with 2 to 5 months of...

Full description

Saved in:
Bibliographic Details
Published inAsia Pacific allergy Vol. 4; no. 3; pp. 180 - 183
Main Authors Pacharn, Punchama, Siripipattanamongkol, Nunthana, Veskitkul, Jittima, Jirapongsananuruk, Orathai, Visitsunthorn, Nualanong, Vichyanond, Pakit
Format Journal Article
LanguageEnglish
Published Korea (South) Asia Pacific Association of Allergy, Asthma and Clinical Immunology 01.07.2014
Subjects
Case Report
Wheat allergy
Immunologic desensitization
Online AccessGet full text

Cover

More Information
Summary:We reported a successful oral immunotherapy (OIT) in 2 children with high wheat sensitivity (4 and 14 years old boys). Oral challenges indicated eliciting doses of 300 mg, and wheat flour of 30 mg. The OIT protocol includes 5 days of build-up phase in the hospital, intervening with 2 to 5 months of home maintenance phase. Patients could tolerate 45 g, and 60 g of wheat flour per day, respectively. We have demonstrated that OIT to a large amount of wheat in extremely sensitized patients could be achieved with a stepwise multi oral/maintenance regimen.
ISSN:2233-8276
2233-8268
DOI:10.5415/apallergy.2014.4.3.180