Drug inhibition indicates a single-site model of the 5-HT uptake site/antidepressant binding site in rat and human brain

Drug inhibition against [3H]paroxetine binding to rat cortex and human putamen was investigated in saturation experiments. The addition of 5-HT, imipramine, citalopram and clomipramine all produced changes in apparent binding affinity (Kd) without changes in the number of binding sites (Bmax). These...

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Bibliographic Details
Published inPsychopharmacology Vol. 99; no. 1; p. 17
Main Authors Marcusson, J O, Andersson, A, Bäckström, I
Format Journal Article
LanguageEnglish
Published Germany 01.01.1989
Subjects
Aged
Animals
Antidepressive Agents - metabolism
Binding Sites
Brain - metabolism
Citalopram - pharmacology
Clomipramine - pharmacology
Humans
In Vitro Techniques
Male
Middle Aged
Paroxetine
Piperidines - metabolism
Rats
Rats, Inbred Strains
Serotonin - metabolism
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Summary:Drug inhibition against [3H]paroxetine binding to rat cortex and human putamen was investigated in saturation experiments. The addition of 5-HT, imipramine, citalopram and clomipramine all produced changes in apparent binding affinity (Kd) without changes in the number of binding sites (Bmax). These data suggest that there is no heterogeneity of specific [3H]paroxetine binding, supporting a single site model of the 5-HT uptake site and antidepressant binding site.
ISSN:0033-3158
DOI:10.1007/BF00634446