Construction of a dual-component hydrogel matrix for 3D biomimetic skin based on photo-crosslinked chondroitin sulfate/collagen
The main challenge in the field of 3D biomimetic skin is to search for a suitable hydrogel matrix with good biocompatibility, appropriate mechanical property and inner porosity that can support the adhesion and proliferation of skin cells. In this study, photocurable chondroitin sulfate methacrylate...
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| Published in | International journal of biological macromolecules Vol. 254; no. Pt 3; p. 127940 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
01.01.2024
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| Abstract | The main challenge in the field of 3D biomimetic skin is to search for a suitable hydrogel matrix with good biocompatibility, appropriate mechanical property and inner porosity that can support the adhesion and proliferation of skin cells. In this study, photocurable chondroitin sulfate methacrylate (CSMA) and collagen methacrylate (CoLMA) synthesized from chondroitin sulfate (CS) and type I collagen I (CoL) in the dermal matrix were used to construct a photo-crosslinked dual-component CSMA-CoLMA hydrogel matrix. Due to the toughening effect of the dual-component, the CSMA-CoLMA hydrogel improved the intrinsic brittleness of the single-component CSMA hydrogel, presented good mechanical tunability. The average storage and elasticity modulus could reach 3.3 KPa and 30.3 KPa, respectively, which were close to those of natural skin. The CSMA-CoLMA hydrogel with a ratio of 8/6 showed suitable porous structure and good biocompatibility, supporting the adhesion and proliferation of skin cells. Furthermore, the expression of characteristic marker proteins was detected in the epidermal and dermal bi-layered models constructed with the hydrogel containing keratinocytes and fibroblasts. These results suggest that the dual-component CSMA-CoLMA hydrogel has promising potential as a matrix to construct 3D biomimetic skin. |
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| AbstractList | The main challenge in the field of 3D biomimetic skin is to search for a suitable hydrogel matrix with good biocompatibility, appropriate mechanical property and inner porosity that can support the adhesion and proliferation of skin cells. In this study, photocurable chondroitin sulfate methacrylate (CSMA) and collagen methacrylate (CoLMA) synthesized from chondroitin sulfate (CS) and type I collagen I (CoL) in the dermal matrix were used to construct a photo-crosslinked dual-component CSMA-CoLMA hydrogel matrix. Due to the toughening effect of the dual-component, the CSMA-CoLMA hydrogel improved the intrinsic brittleness of the single-component CSMA hydrogel, presented good mechanical tunability. The average storage and elasticity modulus could reach 3.3 KPa and 30.3 KPa, respectively, which were close to those of natural skin. The CSMA-CoLMA hydrogel with a ratio of 8/6 showed suitable porous structure and good biocompatibility, supporting the adhesion and proliferation of skin cells. Furthermore, the expression of characteristic marker proteins was detected in the epidermal and dermal bi-layered models constructed with the hydrogel containing keratinocytes and fibroblasts. These results suggest that the dual-component CSMA-CoLMA hydrogel has promising potential as a matrix to construct 3D biomimetic skin. The main challenge in the field of 3D biomimetic skin is to search for a suitable hydrogel matrix with good biocompatibility, appropriate mechanical property and inner porosity that can support the adhesion and proliferation of skin cells. In this study, photocurable chondroitin sulfate methacrylate (CSMA) and collagen methacrylate (CoLMA) synthesized from chondroitin sulfate (CS) and type I collagen I (CoL) in the dermal matrix were used to construct a photo-crosslinked dual-component CSMA-CoLMA hydrogel matrix. Due to the toughening effect of the dual-component, the CSMA-CoLMA hydrogel improved the intrinsic brittleness of the single-component CSMA hydrogel, presented good mechanical tunability. The average storage and elasticity modulus could reach 3.3 KPa and 30.3 KPa, respectively, which were close to those of natural skin. The CSMA-CoLMA hydrogel with a ratio of 8/6 showed suitable porous structure and good biocompatibility, supporting the adhesion and proliferation of skin cells. Furthermore, the expression of characteristic marker proteins was detected in the epidermal and dermal bi-layered models constructed with the hydrogel containing keratinocytes and fibroblasts. These results suggest that the dual-component CSMA-CoLMA hydrogel has promising potential as a matrix to construct 3D biomimetic skin. |
| ArticleNumber | 127940 |
| Author | Huang, Qing Zhang, Xingjiang Wang, Yuzhe Wu, Jianxin He, Shengsheng Chi, Baiyi Li, Huijuan |
| Author_xml | – sequence: 1 givenname: Shengsheng surname: He fullname: He, Shengsheng organization: Center of Skin Health and Cosmetic Development & Evaluation, China Pharmaceutical University, Nanjing 210009, China – sequence: 2 givenname: Huijuan surname: Li fullname: Li, Huijuan email: 1020202616@cpu.edu.cn organization: College of Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address: 1020202616@cpu.edu.cn – sequence: 3 givenname: Baiyi surname: Chi fullname: Chi, Baiyi organization: Center of Skin Health and Cosmetic Development & Evaluation, China Pharmaceutical University, Nanjing 210009, China – sequence: 4 givenname: Xingjiang surname: Zhang fullname: Zhang, Xingjiang organization: Center of Skin Health and Cosmetic Development & Evaluation, China Pharmaceutical University, Nanjing 210009, China – sequence: 5 givenname: Yuzhe surname: Wang fullname: Wang, Yuzhe organization: Center of Skin Health and Cosmetic Development & Evaluation, China Pharmaceutical University, Nanjing 210009, China – sequence: 6 givenname: Jianxin surname: Wu fullname: Wu, Jianxin organization: Center of Skin Health and Cosmetic Development & Evaluation, China Pharmaceutical University, Nanjing 210009, China – sequence: 7 givenname: Qing surname: Huang fullname: Huang, Qing email: huangqingcpu@163.com organization: Center of Skin Health and Cosmetic Development & Evaluation, China Pharmaceutical University, Nanjing 210009, China. Electronic address: huangqingcpu@163.com |
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| Keywords | Photo-crosslinked Chondroitin sulfate Hydrogel matrix Biomimetic skin Collagen |
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