Acute myelomonocytic leukemia with involvement of eosinophils and inversion of chromosome 16

A case of acute nonlymphocytic leukemia (ANLL) with abnormal marrow eosinophils is presented. Thorough morphological, cytochemical, and cytogenetic studies confirm the existence of a recently defined new cytogenetic-morphological entity: acute myelomonocytic leukemia with abnormal bone marrow eosino...

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Bibliographic Details
Published inBlut Vol. 48; no. 5; p. 263
Main Authors Schmitz, N, Gödde-Salz, E, Gassmann, W, Löffler, H
Format Journal Article
LanguageEnglish
Published Germany 01.05.1984
Subjects
Acid Phosphatase - blood
Adult
Carboxylic Ester Hydrolases - blood
Chromosome Aberrations
Chromosomes, Human, 16-18
Chromosomes, Human, 6-12 and X
Cytoplasmic Granules - enzymology
Eosinophils - enzymology
Eosinophils - pathology
Humans
Leukemia, Myeloid - blood
Leukemia, Myeloid - genetics
Male
Periodic Acid-Schiff Reaction
Trisomy
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Summary:A case of acute nonlymphocytic leukemia (ANLL) with abnormal marrow eosinophils is presented. Thorough morphological, cytochemical, and cytogenetic studies confirm the existence of a recently defined new cytogenetic-morphological entity: acute myelomonocytic leukemia with abnormal bone marrow eosinophils (FAB M4), chloracetate esterase- and periodic acid-Schiff-positivity of eosinophilic granules, and pericentric inversion of chromosome 16, in this case combined with trisomy 8. So far 18 such cases have been reported from a single institution. The implications of this new association on the diagnosis of acute leukemia with abnormal eosinophils are discussed.
ISSN:0006-5242
DOI:10.1007/BF00320396