Haemorheologic and fibrinolytic evaluation in obese children and adolescents

The haemorheologic condition was evaluated in 43 obese children and 35 controls. In 18 of the obese children and in 21 controls the euglobulin lysis time (ELT) was also studied. Blood viscosity at 94.5 and at 0.204 s-1 shear rates, plasma viscosity, fibrinogen and erythrocyte filtration time were si...

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Published inEuropean journal of pediatrics Vol. 147; no. 4; p. 381
Main Authors Cacciari, E, Balsamo, A, Palareti, G, Cassio, A, Argento, R, Poggi, M, Tassoni, P, Cicognani, A, Tacconi, M, Pascucci, M G
Format Journal Article
LanguageEnglish
Published Germany 01.05.1988
Subjects
Adolescent
Blood Circulation
Blood Proteins - analysis
Blood Viscosity
Child
Child, Preschool
Erythrocyte Deformability
Female
Fibrinolysis
Hematocrit
Humans
Male
Obesity - blood
Obesity - physiopathology
Rheology
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Summary:The haemorheologic condition was evaluated in 43 obese children and 35 controls. In 18 of the obese children and in 21 controls the euglobulin lysis time (ELT) was also studied. Blood viscosity at 94.5 and at 0.204 s-1 shear rates, plasma viscosity, fibrinogen and erythrocyte filtration time were significantly higher in obese than in control children. No significant differences were observed in haematocrit levels. Triglycerides, non-esterified fatty acids (NEFA), pre-beta-lipoprotein and insulin rates were all significantly higher in obese than in control children. There were no significant differences in glycaemia and in haemoglobin A1 values. ELT, both basal and after stimulation with 1-deamino-8-D-arginine-vasopressin (DDAVP), was significantly higher in the obese than in control children. The haemorheologic disturbances together with alterations of the haemostatic balance and fibrinolysis may be an important risk factor for the development of vascular changes at paediatric age.
ISSN:0340-6199
DOI:10.1007/BF00496415