Hydralazine-Induced Dual Antineutrophil Cytoplasmic Antibody Positive Vasculitis and Nephritis

Drug-induced autoimmunity occurs when exposure to a causative agent leads to serologic or clinical autoimmune responses. Syndromes that may be associated with drug-induced autoimmunity include antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) and drug-induced lupus (DIL). When d...

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Published inCurēus (Palo Alto, CA) Vol. 12; no. 6; p. e8911
Main Authors Padala, Sandeep A, Medepalli, Vidya M, Mohammed, Azeem, Nahman, Stanley
Format Journal Article
LanguageEnglish
Published United States Cureus 29.06.2020
Subjects
Internal Medicine
Nephrology
Rheumatology
antineutrophil cytoplasmic antibody (anca) associated vasculitis (aav)
antineutrophil cytoplasmic antibody (anca)
hydralazine induced dual aav and dil
hydralazine
dual anca aav and dil
drug-induced lupus (dil)
acute kidney injury (aki)
pauci-immune glomerulonephritis (gn)
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Summary:Drug-induced autoimmunity occurs when exposure to a causative agent leads to serologic or clinical autoimmune responses. Syndromes that may be associated with drug-induced autoimmunity include antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) and drug-induced lupus (DIL). When drug-induced autoimmunity involves the kidney, histological patterns of injury include pauci-immune glomerulonephritis (GN), which occurs with AAV, and immune complex-mediated GN, which is associated with DIL. We present a case of hydralazine-induced dual ANCA-positive vasculitis and nephritis.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Report-1
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.8911