Dietary carotenoids block photocarcinogenic enhancement by benzo (a)pyrene and inhibit its carcinogenesis in the dark

• Published in: Experientia Vol. 39; no. 9; p. 1043
• Main Authors: Santamaria, L, Bianchi, A, Arnaboldi, A, Andreoni, L, Bermond, P
• Format: Journal Article
• Language: English
• Published: Switzerland 15.09.1983
• Subjects: Animals; Benzo(a)pyrene; Benzopyrenes - antagonists & inhibitors; beta Carotene; Canthaxanthin; Carotenoids - analogs & derivatives; Carotenoids - pharmacology; Darkness; Diet; Female; Mice; Photochemistry; Skin Neoplasms - prevention & control; Ultraviolet Rays - adverse effects

The carotenoids beta-carotene (C) and canthaxanthine (CX), with and without pro-vitamin A activity, respectively, when perorally administered to mice, markedly prevent benzo(a)pyrene photocarcinogenic enhancement (BP-PCE), continue to block such BP-PCE and protect significantly against BP carcinogen...