Dietary carotenoids block photocarcinogenic enhancement by benzo (a)pyrene and inhibit its carcinogenesis in the dark

The carotenoids beta-carotene (C) and canthaxanthine (CX), with and without pro-vitamin A activity, respectively, when perorally administered to mice, markedly prevent benzo(a)pyrene photocarcinogenic enhancement (BP-PCE), continue to block such BP-PCE and protect significantly against BP carcinogen...

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Bibliographic Details
Published inExperientia Vol. 39; no. 9; p. 1043
Main Authors Santamaria, L, Bianchi, A, Arnaboldi, A, Andreoni, L, Bermond, P
Format Journal Article
LanguageEnglish
Published Switzerland 15.09.1983
Subjects
Animals
Benzo(a)pyrene
Benzopyrenes - antagonists & inhibitors
beta Carotene
Canthaxanthin
Carotenoids - analogs & derivatives
Carotenoids - pharmacology
Darkness
Diet
Female
Mice
Photochemistry
Skin Neoplasms - prevention & control
Ultraviolet Rays - adverse effects
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Summary:The carotenoids beta-carotene (C) and canthaxanthine (CX), with and without pro-vitamin A activity, respectively, when perorally administered to mice, markedly prevent benzo(a)pyrene photocarcinogenic enhancement (BP-PCE), continue to block such BP-PCE and protect significantly against BP carcinogenesis in mice maintained in the dark. These results appear relevant to both the pathogenesis of chemical carcinogenesis and rational programs of skin cancer prevention in humans.
ISSN:0014-4754
DOI:10.1007/BF01989795