Acute renal cortical necrosis in a series of young men with severe acute pancreatitis

Diffuse renal cortical necrosis from any cause is rare in the Western World. Over the last 5 decades, there have been isolated case reports of acute cortical necrosis as a consequence of acute pancreatitis, but the long-term outcome of these patients has not previously been reported. Here, we report...

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Bibliographic Details
Published inClinical nephrology Vol. 66; no. 4; p. 223
Main Authors Alfonzo, A V M, Fox, J G, Imrie, C W, Roditi, G, Young, B
Format Journal Article
LanguageEnglish
Published Germany 01.10.2006
Subjects
Acute Disease
Acute Kidney Injury - therapy
Adolescent
Adult
Anuria - etiology
Humans
Kidney Cortex Necrosis - complications
Kidney Cortex Necrosis - therapy
Kidney Transplantation - rehabilitation
Male
Pancreatitis - complications
Pancreatitis - therapy
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Summary:Diffuse renal cortical necrosis from any cause is rare in the Western World. Over the last 5 decades, there have been isolated case reports of acute cortical necrosis as a consequence of acute pancreatitis, but the long-term outcome of these patients has not previously been reported. Here, we report 3 young men, aged 16-21 years, who have presented over the past 19 years with severe acute pancreatitis associated with oliguric acute renal failure. They were all found to have diffuse renal cortical necrosis and consequently made no renal recovery. Despite the appreciable mortality associated with acute pancreatitis complicated by acute renal failure, they all survived the initial illness and all have successfully undergone renal transplantation. We present a detailed account of each patient including diagnostic strategies and discuss the possible factors contributing to a favorable outcome in these patients.
ISSN:0301-0430
DOI:10.5414/cnp66223