Epithelial HLA-DR expression and lymphocyte subsets in gastric mucosa in type B chronic gastritis

Lymphocyte subpopulations (B, T4, T8), monocytes/macrophages (LeuM5, KiM5) and HLA-DR antigen expression were studied immunohistochemically in frozen sections from 32 antral and 37 fundal biopsies of type-B chronic gastritis. Aberrant HLA-DR antigen expression in epithelial cells of gastric mucosa w...

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Published inVirchows Archiv. A, Pathological anatomy and histopathology Vol. 413; no. 3; p. 197
Main Authors Papadimitriou, C S, Ioachim-Velogianni, E E, Tsianos, E B, Moutsopoulos, H M
Format Journal Article
LanguageEnglish
Published Germany 01.01.1988
Subjects
Chronic Disease
Gastric Mucosa - immunology
Gastric Mucosa - pathology
Gastritis - immunology
Gastritis - pathology
HLA-D Antigens - immunology
HLA-DR Antigens - immunology
Humans
Lymphocytes - classification
Lymphocytes - immunology
Lymphocytes - pathology
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Summary:Lymphocyte subpopulations (B, T4, T8), monocytes/macrophages (LeuM5, KiM5) and HLA-DR antigen expression were studied immunohistochemically in frozen sections from 32 antral and 37 fundal biopsies of type-B chronic gastritis. Aberrant HLA-DR antigen expression in epithelial cells of gastric mucosa was found in all cases closely related to mononuclear infiltrates. Epithelial HLA-DR expression and mononuclear infiltrates were practically absent in foci of intestinal metaplasia. These findings suggest that an immunopathologic mechanism probably plays a role in initiation or perpetuation of type-B chronic gastritis.
ISSN:0174-7398
DOI:10.1007/BF00718611