Prevalence of factor V Leiden and activated protein C resistance in central retinal vein occlusion

• Published in: Retina (Philadelphia, Pa.) Vol. 21; no. 2; p. 161
• Main Authors: Johnson, T M, El-Defrawy, S, Hodge, W G, Leonard, B C, Kertes, P J, Taylor SAM, Lillicrap, D P
• Format: Journal Article
• Language: English
• Published: United States 01.01.2001
• Subjects: Activated Protein C Resistance - blood; Activated Protein C Resistance - complications; Aged; Case-Control Studies; Factor V - metabolism; Female; Humans; Male; Middle Aged; Odds Ratio; Point Mutation; Polymerase Chain Reaction; Prevalence; Retinal Vein Occlusion - blood; Retinal Vein Occlusion - complications; Risk Factors
• ISSN: 0275-004X
• DOI: 10.1097/00006982-200104000-00010

Factor V Leiden is a common inherited mutation that is a significant risk factor for deep vein thrombosis. It results in resistance to activated protein C (APC). The association between factor V Leiden and central retinal vein occlusion (CRVO) remains controversial. This study was designed to determine the prevalence of APC resistance and the factor V Leiden mutation in patients with CRVO in a controlled study. The study was designed as a case control study conducted in a tertiary care retina practice. The prevalence of APC resistance and factor V Leiden was determined by genetic testing of blood samples obtained from patients with CRVO and clinic control patients. Factor V Leiden was identified in 2.3% of patients with CRVO and 3.5% of clinic control patients. There was no significant association between the presence of factor V Leiden and CRVO (odds ratio, 1.13; 95% confidence interval, 0.65-1.98; P = 0.66). Factor V Leiden does not appear to be associated with CRVO. Routine screening of patients with CRVO does not appear to be warranted.