Pharmacokinetic study of i.v. infusions of adriamycin

The plasma pharmacokinetics of adriamycin has been studied in 21 cancer patients (31-85 years old) without liver tumours after short (3.00 min) and prolonged (45 min-16 h) i.v. infusions. The area under the plasma concentration-time curve and the maximum plasma concentration compensated for dose var...

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Bibliographic Details
Published inEuropean journal of clinical pharmacology Vol. 28; no. 2; p. 205
Main Authors Eksborg, S, Strandler, H S, Edsmyr, F, Näslund, I, Tahvanainen, P
Format Journal Article
LanguageEnglish
Published Germany 01.01.1985
Subjects
Adult
Age Factors
Aged
Doxorubicin - administration & dosage
Doxorubicin - adverse effects
Doxorubicin - metabolism
Female
Humans
Infusions, Parenteral
Kinetics
Male
Middle Aged
Time Factors
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Summary:The plasma pharmacokinetics of adriamycin has been studied in 21 cancer patients (31-85 years old) without liver tumours after short (3.00 min) and prolonged (45 min-16 h) i.v. infusions. The area under the plasma concentration-time curve and the maximum plasma concentration compensated for dose variation showed a more than 3-fold individual variation. The pharmacokinetics of adriamycin was linear. There was no pharmacokinetic rational for variation of the dose with the age of the patients. There was good agreement between the measured plasma concentration-time curves for prolonged infusions and curves predicted from pharmacokinetic data from short term infusions.
ISSN:0031-6970
DOI:10.1007/BF00609693