A new antiangiogenic C24 oxylipin from the soft coral Sinularia numerosa

A new oxylipin, 15-hydroxy-tetracosa-6,9,12,16,18-pentaenoic acid (15-HTPE; 1) was isolated as an inhibitor of tube-formation from the soft coral Sinularia numerosa. Its structure was elucidated by means of spectral analysis and chemical degradation. 15-HTPE inhibited tube formation of EA.hy926 cell...

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Published inBioorganic & medicinal chemistry Vol. 17; no. 6; pp. 2181 - 2184
Main Authors Yamashita, Takahiro, Nakao, Yoichi, Matsunaga, Shigeki, Oikawa, Tsutomu, Imahara, Yukimitsu, Fusetani, Nobuhiro
Format Journal Article
LanguageEnglish
Published England 15.03.2009
Subjects
Angiogenesis Inhibitors - chemistry
Angiogenesis Inhibitors - isolation & purification
Angiogenesis Inhibitors - pharmacology
Animals
Anthozoa - chemistry
Magnetic Resonance Spectroscopy
Molecular Structure
Oxylipins - chemistry
Oxylipins - isolation & purification
Oxylipins - pharmacology
Sinularia numerosa
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Summary:A new oxylipin, 15-hydroxy-tetracosa-6,9,12,16,18-pentaenoic acid (15-HTPE; 1) was isolated as an inhibitor of tube-formation from the soft coral Sinularia numerosa. Its structure was elucidated by means of spectral analysis and chemical degradation. 15-HTPE inhibited tube formation of EA.hy926 cells at the concentration of 20-40 microM.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2008.10.083