Growth inhibitory effect of antibiotic tetaine on yeast and mycelial forms of Candida albicans

The mycelial (M) form of Candida albicans is more sensitive to the action of the antibiotic tetaine than the yeast (Y) form. Tetaine, at low concentrations about 1 microgram/ml also inhibits Y-M transition. It causes severe deformation of cells, agglutination and inhibits septum formation in the yea...

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Bibliographic Details
Published inArchives of microbiology Vol. 135; no. 2; p. 130
Main Authors Milewski, S, Chmara, H, Borowski, E
Format Journal Article
LanguageEnglish
Published Germany 01.08.1983
Subjects
Amino Acids - pharmacology
Amino Sugars - pharmacology
Anti-Bacterial Agents - pharmacology
Candida albicans - cytology
Candida albicans - drug effects
Candida albicans - growth & development
Dipeptides - pharmacology
Peptides - pharmacology
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Summary:The mycelial (M) form of Candida albicans is more sensitive to the action of the antibiotic tetaine than the yeast (Y) form. Tetaine, at low concentrations about 1 microgram/ml also inhibits Y-M transition. It causes severe deformation of cells, agglutination and inhibits septum formation in the yeast forms. Tetaine action is reversed by dipeptides in both forms and by tripeptides in M form. N-acetyl glucosamine is a powerful antagonist of tetaine action on both morphological forms. Tetaine action on mycelial forms is slightly antagonised by N-acetyl mannosamine and very powerfully by glutamine.
ISSN:0302-8933
DOI:10.1007/BF00408022