Investigations of chromosomal stability in the Gorlin-Goltz syndrome

Chromosomal studies were carried out on nine patients with the Gorlin-Goltz syndrome using recently developed methods on cultured lymphocytes. In addition, the dermatoglyphics of these patients were examined. No evidence of a characteristic chromosome aberration was found in banded prometaphase-chro...

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Bibliographic Details
Published inArchives of dermatological research Vol. 277; no. 5; p. 370
Main Authors Römke, C, Gödde-Salz, E, Grote, W
Format Journal Article
LanguageEnglish
Published Germany 01.01.1985
Subjects
Basal Cell Nevus Syndrome - genetics
Basal Cell Nevus Syndrome - pathology
Carcinoma, Basal Cell - genetics
Cells, Cultured
Chromosome Fragility
Chromosomes, Human - ultrastructure
Chromosomes, Human, 1-3 - ultrastructure
Dermatoglyphics
Female
Humans
Karyotyping
Lymphocytes - ultrastructure
Male
Mitomycin
Mitomycins - pharmacology
Sister Chromatid Exchange - drug effects
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Summary:Chromosomal studies were carried out on nine patients with the Gorlin-Goltz syndrome using recently developed methods on cultured lymphocytes. In addition, the dermatoglyphics of these patients were examined. No evidence of a characteristic chromosome aberration was found in banded prometaphase-chromosome preparations, nor could increased chromosome breakage be demonstrated in eight of the patients. One proposita showed frequent breaks of Chromosome 1 at p22. Increased chromosome instability in these patients was suggested by higher spontaneous and mitomycin-C-induced sister chromatid exchange rates in patients than in controls. Although the dermatoglyphic findings cannot be regarded as specific for the Gorlin-Goltz syndrome, an increased occurrence of whorl patterns and white lines in patients' fingerprints was noted.
ISSN:0340-3696
1432-069X
DOI:10.1007/BF00509235