Clinical significance of anticentromere antibody in primary biliary cirrhosis

• Published in: Kanzo Vol. 30; no. 11; pp. 1578 - 1583
• Main Authors: UENO, Yukihisa, SADAMOTO, Takaaki, ONOZUKA, Yasushi, SATO, Genichiro, SHIBATA, Minoru, NONAKA, Hiroko, YOSHIDA, Naoya, SUMINO, Yasukiyo
• Format: Journal Article
• Language: Japanese
• Published: The Japan Society of Hepatology 1989
• Subjects: ACA; AMA; PBC
• ISSN: 0451-4203; 1881-3593
• DOI: 10.2957/kanzo.30.1578

Serum anticentromere antibody (ACA) was measured in 123 cases of various chronic liver diseases and especially in primary biliary cirrhosis (PBC), the relationship between the positiveness of ACA and symptom, laboratory data, histology and clinical course was studied. Subjects were 123 cases of chronic liver disease, 25 cases of PBC, 11 cases of lupoid hepatitis and 87 cases of other chronic liver diseases (73 of viral and 14 of alcoholic). Prevalence of ACA was highest (44%) in patients with PBC compared with other chronic liver disease. In PBC patient, most ACA positive cases were asymptomatic and complicated with extra hepatic symptoms of CREST syndrome (82%) and showed low titer of antimitochondria antibody (AMA), low levels of serum IgM and bilirubin, gradually progressive clinical course, histologically mild changes, and prognosis was suspected good compared with ACA negative cases. Therefore, in ACA positive cases there might be a distinct of PBC different from that in ACA negative cases.