Etiopathogenesis of acute hepatic failure: Eastern versus Western countries

Etiopathogenesis of acute hepatic failure (AHF) in Eastern and Western countries is distinct. In the East hepatitis viruses cause AHF in more than 95% of such cases, while causes of AHF in the West are quite heterogenous. Hepatitis E virus is the major etiological agent of AHF in countries like Indi...

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Published inJournal of gastroenterology and hepatology Vol. 17; no. s3; pp. S268 - S273
Main Authors ACHARYA, SK, BATRA, Y, HAZARI, S, CHOUDHURY, V, PANDA, SK, DATTAGUPTA, S
Format Journal Article
LanguageEnglish
Published Melbourne, Australia Blackwell Science Pty 01.12.2002
Subjects
Europe
Humans
India
Liver Failure, Acute - etiology
Liver Failure, Acute - pathology
United States
United States
Europe
India
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Summary:Etiopathogenesis of acute hepatic failure (AHF) in Eastern and Western countries is distinct. In the East hepatitis viruses cause AHF in more than 95% of such cases, while causes of AHF in the West are quite heterogenous. Hepatitis E virus is the major etiological agent of AHF in countries like India where the virus is hyperendemic. Occult HBV infection may also be causing AHF in a sizable proportion of cases in areas where chronic HBV infection frequency is high. Paracetamol causes AHF in about 70% cases in the UK and about 20% cases in USA, whereas in France and Denmark, non‐steroidal anti‐inflammatory drugs are more frequently associated with AHF. Hepatitis B virus causes AHF in about one‐third of cases in the latter two countries. © 2002 Blackwell Publishing Asia Pty Ltd
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ISSN:0815-9319
1440-1746
DOI:10.1046/j.1440-1746.17.s3.12.x