Current status of Helicobacter pylori eradication and risk factors for eradication failure
The ( ) eradication rate is decreasing in the general population of China. To evaluate the eradication status in real-world clinical practice and to explore factors related to eradication failure. Patients with infection who were treated with standard 14-d quadruple therapy and received a test of cu...
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Published in | World journal of gastroenterology : WJG Vol. 26; no. 32; pp. 4846 - 4856 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Baishideng Publishing Group Inc
28.08.2020
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Subjects | |
Online Access | Get full text |
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Summary: | The
(
) eradication rate is decreasing in the general population of China.
To evaluate the
eradication status in real-world clinical practice and to explore factors related to eradication failure.
Patients with
infection who were treated with standard 14-d quadruple therapy and received a test of cure at a provincial medical institution between June 2018 and May 2019 were enrolled. Demographic and clinical data were recorded. Eradication rates were calculated and compared between regimens and subgroups. Multivariate analysis was performed to identify predictors of eradication failure.
Of 2610 patients enrolled, eradication was successful in 1999 (76.6%) patients. Amoxicillin-containing quadruple regimens showed a higher eradication rate than other quadruple therapy regimens (83.0%
69.0%,
< 0.001). The quadruple therapy containing amoxicillin plus clarithromycin achieved the highest eradication rate (83.5%). Primary therapy had a higher eradication rate than rescue therapy (78.3%
66.5%,
< 0.001). In rescue therapy, the amoxicillin- and furazolidone-containing regimens achieved the highest eradication rate (80.8%). Esomeprazole-containing regimens showed a higher eradication rate than those containing other proton pump inhibitors (81.8%
74.9%,
= 0.001). Multivariate regression analysis found that older age, prior therapy, and use of omeprazole or pantoprazole were associated with an increased risk of eradication failure.
The total eradication rate is 76.6%. Amoxicillin-containing regimens are superior to other regimens. Age, prior therapy, and use of omeprazole or pantoprazole are independent risk factors for eradication failure. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Author contributions: Yan TL and Gao JG contributed equally to this work; Xu CF, Yan TL, and Lu C designed the research; Yan TL, Gao JG, and Chen D performed the research; Wang JH analyzed the data; Yan TL and Xu CF drafted and revised the manuscript. All authors approved the final draft of this manuscript for submission. Corresponding author: Cheng-Fu Xu, MD, Doctor, Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. xiaofu@zju.edu.cn Supported by the National Natural Science Foundation of China, No. 81600447. |
ISSN: | 1007-9327 2219-2840 |
DOI: | 10.3748/WJG.V26.I32.4846 |