Effect of neonatal thymectomy on D-galactosamine induced liver injury in mice

• Published in: Kanzo Vol. 31; no. 10; pp. 1204 - 1209
• Main Authors: MASUDA, Kazunari, WATANABE, Yasuyuki, NAKANISHI, Toshio, IKEMOTO, Yoshihiro, KOMATSU, Koichi, ITOH, Hiroyuki, KITAMOTO, Mikiya, KOHNO, Hiroshi, AMANO, Hazime, TAMURA, Tohru, NAKAMURA, Toshio, MIURA, Toshio, KAMIYASU, Masaya, KAZIYAMA, Goro, YAMAMOTO, Masami
• Format: Journal Article
• Language: English; Japanese
• Published: The Japan Society of Hepatology 1990
• Subjects: liver-specific membrane lipoprotein; Suppressor cell
• ISSN: 0451-4203; 1881-3593
• DOI: 10.2957/kanzo.31.1204

To evaluate the various influences of neonatal thymectomy on galactosamine (Gal-N) induced tiver injury in A/J mice, we serially observed histological changes in the liver and serum autoantibody to liver-specific membrane lipoprotein (LSP) in normal mice, mice thymectamized 2-3 days after birth (Tx 2-3 mice), and those thyrnectornized 5 days after birth (Tx 5 mice). In the normal and Tx 2-3 mice, massive hepatocyte necrosis was observed in the acute stage. Then in the normal mice, hepatitis healed 1 week after Gal-N administration, and autoantibody to LSP was always negative. However, in Tx 2-3 mice, considerable mononuclear cell infiltration in the portal area was frequently observed even 3 months after Gal-N administration, and the serum level of autoantibody to LSP remained high. On the other hand, Tx 5 mice showed findings similar to those in the normal mice. These results suggest that healing of Gal-N induced liver injury is delayed by thymectomy 2-3 days after birth due to sensitization with LSP preparations.