Effectiveness of cognitive remediation in subjects with major depressive disorder: A multicenter randomized controlled study in a real-world setting

• Published in: European psychiatry Vol. 68; no. 1; p. e106
• Main Authors: Barlati, Stefano, Nibbio, Gabriele, Bellomo, Antonello, Carpiniello, Bernardo, Colombo, Cristina, De Giorgi, Serafino, Deste, Giacomo, Maina, Giuseppe, Martinotti, Giovanni, Tortorella, Alfonso, Di Salvo, Gabriele, Luciano, Mario, Pinna, Federica, Ventriglio, Antonio, Fiorillo, Andrea, Vita, Antonio
• Format: Journal Article
• Language: English
• Published: England Cambridge University Press 2025
• Subjects: Adult; Clinical outcomes; Clinical trials; cognition; Cognitive ability; Cognitive Dysfunction - etiology; Cognitive Dysfunction - rehabilitation; Cognitive Dysfunction - therapy; cognitive rehabilitation; cognitive remediation; Cognitive Remediation - methods; cognitive training; Consent; depression; Depressive Disorder, Major - complications; Depressive Disorder, Major - rehabilitation; Depressive Disorder, Major - therapy; Female; Humans; Intervention; Male; Medical research; Mental depression; Mental disorders; Mental health; Meta-analysis; Middle Aged; Neurosciences; Outcome Assessment, Health Care; Psychiatry; Psychosis; Psychosocial Functioning; RCT; Schizophrenia; Single-Blind Method; Software; Therapists; Therapy, Computer-Assisted; RCT; depression; cognition; cognitive remediation; cognitive rehabilitation; cognitive training

Cognitive impairment represents a central component of major depressive disorder (MDD), affecting a large proportion of people living with MDD and showing a consistent negative impact on social, interpersonal, and occupational functioning and subjective quality of life. Cognitive remediation (CR) is...