Hyperandrogenism in a girl with Turner syndrome: A case report

• Published in: Medicine (Baltimore) Vol. 98; no. 34; p. e16845
• Main Authors: Diao, Yuchao, Zheng, Qingmei, Chen, Zhihong, Dai, Shuzhen, Yao, Qin
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health 01.08.2019
• Subjects: Adolescent; Clinical Case Report; Female; Gonads - pathology; Gonads - surgery; Humans; Hyperandrogenism - complications; Polymerase Chain Reaction; Testosterone - blood; Turner Syndrome - complications
• ISSN: 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000016845

The gonads of patients with Turner syndrome (TS) were previously thought to be funicular. There was no increase in androgen level. The gonad that is testis should be taken into account when the patient's serum testosterone level was abnormal and hypothalamic-pituitary-adrenal disease was excepted. A 16-year-old girl was admitted to our hospital because of chromosomal abnormalities and elevated androgen levels. Turner syndrome could be diagnosed since her chromosome karyotype was 45, XO. The patient was given bilateral gonadectomy and hormone replacement therapies. The level of the patient's serum testosterone was <0.45 nmol/L 2 days after the operation. Postoperative pathology showed that her right gonad was testicular tissue. The patient's menstruation was normal after the treatment of hormone replacement therapy. All TS patients should get Y chromosome material screening. Gonadectomy could be done for Turner syndrome patients who have hyperandrogenism or Y chromosome material.