The role of recombinant human brain natriuretic peptide on the cardiac output of patients with acute decompensated heart failure using Guyton venous return curve: A STROBE-compliant retrospective study

• Published in: Medicine (Baltimore) Vol. 100; no. 17; p. e25492
• Main Authors: Liu, Jian Ling, Zhang, Xiao Fei, Liu, Zhi, Li, Jie Min, Wen, Zhen Jie, Zhang, Ming, Lin, Qin Han, Kou, Qiu Ye
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 30.04.2021
• Subjects: Acute Disease; Aged; Cardiac Output - drug effects; Female; Heart Failure - drug therapy; Heart Failure - physiopathology; Humans; Male; Middle Aged; Models, Cardiovascular; Natriuretic Peptide, Brain - therapeutic use; Observational Study; Recombinant Proteins - therapeutic use; Retrospective Studies; Treatment Outcome; Vascular Resistance - drug effects
• ISSN: 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000025492

rbBNP has positive cardiac effects in patients with acute decompensated heart failure, but its effects on the systemic venous circulation are not known.A single-center retrospective, self-controlled study was conducted on 14 patients undergone recombinant human brain natriuretic peptide (rhBNP) treatment between January 1, 2015 to December 31, 2018.The cardiac output (CO) significantly increased from 3.75 ± 1.14 L min-1 to 4.24 ± 0.97 L min-1 30 minutes after rbBNP infusion, and to 4.20 ± 1.19 L min-1 3 hours later. The systemic vascular resistance significantly decreased from 18.85 ± 7.66 mm Hg min L-1 to 14.62 ± 6.13 mm Hg min L-1 30 minutes. The resistance to venous return (VR) significantly decreased from 5.93 ± 4.97 mm Hg min L-1 to 4.46 ± 1.53 mmHg min L-1 3 hours later. The mean systemic filling pressure significantly decreased from 32.71 ± 20.00 mm Hg to 28.254 ± 6.09 mm Hg 3 hours later.The role of rhBNP on CO was to reduce the peripheral circulation resistance at 30 minutes after rhBNP infusion and to reduce the resistance to VR at 3 hours later.This trial is registered at ChiCTR: ID ChiCTR1900024562.