A facile one-pot, four-component synthesis of (Z)-isomer of rhodanine-oxindole derivatives under environmentally benevolent conditions

Herein, an efficient and sustainable one-pot, four-component access to rhodanine-oxindole derivatives is achieved by a reaction between primary amines, carbon disulfide, ethyl chloroacetate, and cyano-substituted alkenyl oxindoles. The reaction was conducted without any harsh conditions as well as e...

Full description

Saved in:
Bibliographic Details
Published inSynthetic communications Vol. 52; no. 2; pp. 175 - 184
Main Authors Moghaddam, F. Matloubi, Aghamiri, Bagher, Jalalinik, Mahbod
Format Journal Article
LanguageEnglish
Published PHILADELPHIA Taylor & Francis 17.01.2022
Subjects
Chemistry
Chemistry, Organic
Dithiocarbamate
green synthesis
multi-component reaction
oxindole
Physical Sciences
rhodanine
Science & Technology
multi-component reaction
CYCLOADDITION REACTIONS
DISPIROPYRROLIDINES
Dithiocarbamate
oxindole
green synthesis
rhodanine
Online AccessGet full text

Cover

More Information
Summary:Herein, an efficient and sustainable one-pot, four-component access to rhodanine-oxindole derivatives is achieved by a reaction between primary amines, carbon disulfide, ethyl chloroacetate, and cyano-substituted alkenyl oxindoles. The reaction was conducted without any harsh conditions as well as exhausting workup in polyethylene glycol (PEG) as a green solvent at room temperature and delivered rhodanine-oxindole products in high yield. This publication is the first easy protocol to be reported for the rapid construction of new rhodanine-oxindole derivatives at room temperature without harsh conditions and via multicomponent reaction.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2021.2008445