Efficacy of phenylephrine-phenylpropanolamine in the treatment of rhinitis
A double-blind placebo-controlled crossover study was done to evaluate the efficacy of an oral decongestant preparation in the treatment of rhinitis. The preparation consisted of 5 mg of phenylephrine hydrochloride, 45 mg of phenylpropanolamine hydrochloride, and 200 mg of guaifenesin (Rymed). Subje...
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Published in | Southern medical journal (Birmingham, Ala.) Vol. 75; no. 5; p. 562 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.05.1982
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Subjects | |
Online Access | Get more information |
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Summary: | A double-blind placebo-controlled crossover study was done to evaluate the efficacy of an oral decongestant preparation in the treatment of rhinitis. The preparation consisted of 5 mg of phenylephrine hydrochloride, 45 mg of phenylpropanolamine hydrochloride, and 200 mg of guaifenesin (Rymed). Subjects were selected for participation in the study on the basis of history, physical examination, and immediate hypersensitivity skin testing. Fourteen of 20 subjects (P less than .05) observed a reduction in the severity of nasal symptoms while taking the drug. The mean symptom score of the 20 subjects while taking the drug was 31.344 and while taking placebo, 42.979. This is a statistically significant difference (P = .009717). Side effects were minimal. We concluded that the oral decongestant preparation used in this study is effective in controlling symptoms of rhinitis. |
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ISSN: | 0038-4348 1541-8243 |
DOI: | 10.1097/00007611-198205000-00014 |