Volatile organic compounds fingerprinting in faeces and urine of Alzheimer's disease model SAMP8 mice by headspace-gas chromatography-ion mobility spectrometry and headspace-solid phase microextraction-gas chromatography-mass spectrometry

• Published in: Journal of Chromatography A Vol. 1614; p. 460717
• Main Authors: Tian, Hehe, Li, Siying, Wen, Haichao, Zhang, Xiaoxu, Li, Jingming
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.03.2020
• Subjects: Alzheimer disease; amino acids; amyloidosis; animal models; bacterial growth; brain damage; cataract; cognition; cognitive disorders; cortex; disease models; drugs; fatty acids; feces; food quality; gas chromatography-mass spectrometry; genes; headspace analysis; health status; hippocampus; humans; ionization; longevity; memory; memory disorders; metabolism; metabolites; mice; monitoring; neurodegenerative diseases; neurons; neurotransmitters; osteoarthritis; osteoporosis; pathogenesis; patients; people; peptides; phenotype; positron-emission tomography; protein content; proteins; reproduction; signs and symptoms (animals and humans); solid phase microextraction; South Korea; Spain; synapse; urine; volatile organic compounds; South Korea; Spain
• ISSN: 0021-9673; 1873-3778
• DOI: 10.1016/j.chroma.2019.460717

•GC-IMS was used to distinguish the compositional differences of VOCs in AD.•The VOCs of faeces and urine of AD-model mice were qualified and quantified.•The PLS-DA models established by GC-IMS and GC–MS could identify AD, respectively.•GC-IMS could be used as a complementary technique to GC–MS for AD diagnosis.