Attenuating effects of diazepam on the electroretinogram of normal humans

Response/log I curves were obtained under conditions of dark-and light-adaptation in seven normal male volunteers. For each subject, a baseline electroretinogram (ERG) was recorded. In the same afternoon, a second ERG was obtained after 0.05 mg/kg diazepam, and a third ERG was recorded following 0.1...

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Bibliographic Details
Published inRetina (Philadelphia, Pa.) Vol. 9; no. 3; p. 216
Main Authors Jaffe, M J, Hommer, D W, Caruso, R C, Straw, G M, de Monasterio, F M
Format Journal Article
LanguageEnglish
Published United States 1989
Subjects
Adult
Dark Adaptation
Diazepam - pharmacology
Dopamine - metabolism
Dose-Response Relationship, Drug
Electroretinography - drug effects
Humans
Male
Oscillometry
Photoreceptor Cells - drug effects
Photoreceptor Cells - metabolism
Random Allocation
Retina - drug effects
Retina - metabolism
Time Factors
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Summary:Response/log I curves were obtained under conditions of dark-and light-adaptation in seven normal male volunteers. For each subject, a baseline electroretinogram (ERG) was recorded. In the same afternoon, a second ERG was obtained after 0.05 mg/kg diazepam, and a third ERG was recorded following 0.10 mg/kg diazepam. Under conditions of dark-adaptation, the following dose-dependent changes were identified: 1) Diazepam attenuated the rod b-wave peak amplitude and increased its implicit time; 2) The dark-adapted longer wavelength cone a-wave and 'blue cone' b-wave showed an increased implicit time; 3) All oscillatory potentials showed an increased implicit time. Under conditions of light-adaptation, dose-dependent decreases in peak amplitude and delays in implicit time were observed for the a- and b-waves. The effects of diazepam on the human ERG were more profound under conditions of light- than dark-adaptation.
ISSN:0275-004X
DOI:10.1097/00006982-198909030-00010