Comparison of the antihypertensive efficacy of morning and bedtime dosing on reducing morning blood pressure surge: A protocol for systemic review and meta-analysis

• Published in: Medicine (Baltimore) Vol. 100; no. 5; p. e24127
• Main Authors: Zhang, Peng, Jin, Mei-Ying, Song, Xu-Yu, Wang, Zhao, Jiang, Yue-Hua, Yang, Chuan-Hua
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 05.02.2021
• Subjects: Antihypertensive Agents - administration & dosage; Antihypertensive Agents - pharmacokinetics; Blood Pressure - drug effects; Blood Pressure - physiology; Blood Pressure Monitoring, Ambulatory - methods; Drug Chronotherapy; Humans; Hypertension - diagnosis; Hypertension - drug therapy; Meta-Analysis as Topic; Research Design; Study Protocol Systematic Review; Systematic Reviews as Topic; Treatment Outcome
• ISSN: 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000024127

It is well known that morning blood pressure surge increases the risk of myocardial events in the first several hours post-awakening. This meta-analysis was performed to compare the antihypertensive efficacy of morning and bedtime dosing on decreasing morning blood pressure surge. Articles in 4 databases about clinical trials of ingestion time of antihypertensive drugs were searched and performed a meta-analysis to evaluate the different effects on morning blood pressure and absolute blood pressure (BP) reduction from baseline of between bedtime administration (experimental group) and morning awaking administration (control group). The aim of this study is to compare the antihypertensive efficacy of morning and bedtime dosing on decreasing morning blood pressure surge. The bedtime will provide evidence support for clinicians and patients for reducing morning blood pressure surge. This study does not require ethical approval.