Different vitamin K forms in hemodialysis patients: a simple dietary supplement to battle vascular calcification—randomized controlled trial

• Published in: The Egyptian journal of internal medicine Vol. 35; no. 1; pp. 4 - 7
• Main Authors: Elshinnawy, Howaida Abdelhameed, El-Said, Tamer Wahid, Fahmy, Sarah Farid, Shamseldin, Ahmed, Ibrahim, Sherin, Elsharabasy, Reem Mohsen
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 23.01.2023; Springer Nature B.V; SpringerOpen
• Subjects: Blood vessels; Calcification; Heart failure; Hemodialysis; Hemodialysis; Vascular calcification; Internal Medicine; Laboratories; Medicine; Medicine & Public Health; MGP; Mortality; Patients; Pharmacists; Proteins; School dropout programs; Vitamin K supplements; Vitamin k1; Vitamin k2; Egypt; Vitamin k1; Vitamin k2; Hemodialysis; Vascular calcification; Vitamin K supplements; MGP
• ISSN: 2090-9098; 1110-7782; 2090-9098
• DOI: 10.1186/s43162-022-00181-1

Background and aim Vascular calcification is a significant risk factor for cardiovascular diseases in patients with end-stage renal disease, particularly those on hemodialysis. Previous research on vitamin K found that it had a positive on calcification markers. However, clinical data is still limited. This study aimed to compare the efficacy and safety of vitamin K2 versus vitamin k1 on a calcification regulator in hemodialysis patients. Methods A prospective randomized placebo-controlled trial was conducted on 120 patients, who were divided into three groups; group 1: administered 10 mg of vitamin K1 (phytomenadione thrice weekly); group 2: administered 90 μg of vitamin k2 (MK-7); group 3: administered placebo for 3 months. Matrix Gla protein (MGP), calcium, phosphorous, and intact parathyroid hormone levels were measured. Results MK-7 significantly increased active MGP levels compared to phytomenadione and placebo groups ( p <0.0001). No correlations were found between calcium, phosphorous, PTH, and MGP levels at baseline or after treatment. Conclusion Vitamin k supplementation was effective and tolerable in modulating MGP in hemodialysis patients, with MK-7 outperforming phytomenadione.