Low selection of preneoplastic hepatocytes after treatment with the 2-acetylaminofluorene diet-partial hepatectomy regimen in the liver of hepatocarcinogenesis-resistant DRH strain rats

• Published in: Oncology reports Vol. 17; no. 1; pp. 55 - 60
• Main Authors: IMAI, Koji, YAMAMOTO, Masahiro, OGAWA, Katsuhiro, TANAKA, Hiroki, HASHIMOTO, Norikazu, MIYAKOSHI, Masaaki, HONMOU, Satoshi, YOSHIE, Masumi, TAMAKAWA, Susumu, YAGINUMA, Yuji, KASAI, Shinichi
• Format: Journal Article
• Language: English
• Published: Athens S.n. 2007
• Subjects: 2-Acetylaminofluorene - administration & dosage; Animals; Biological and medical sciences; Carcinogens - administration & dosage; Cell Growth Processes - drug effects; Gastroenterology. Liver. Pancreas. Abdomen; Genetic Predisposition to Disease; Glutathione Transferase - biosynthesis; Hepatectomy; Hepatocytes - drug effects; Hepatocytes - enzymology; Hepatocytes - pathology; Hepatocytes - transplantation; Liver Neoplasms, Experimental - chemically induced; Liver Neoplasms, Experimental - enzymology; Liver Neoplasms, Experimental - genetics; Liver Neoplasms, Experimental - pathology; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Neoplasm Transplantation; Precancerous Conditions - chemically induced; Precancerous Conditions - enzymology; Precancerous Conditions - genetics; Precancerous Conditions - pathology; Rats; Rats, Inbred Strains; Tumors; Rat; preneoplastic hepatocytes; Selection; Hepatic disease; Transplantation; hepatocarcinogenesis; Carcinogenesis; Hepatectomy; Liver cancer; Cancerology; Hepatocyte; Partial; Glutathione transferase; Surgery; Graft; Premalignant lesion; Nutrition; GST-P; Digestive system; Enzyme; Transferases; Rodentia; Malignant tumor; Feeding; Strain; Resistance; DRH rats; Vertebrata; Mammalia; Treatment; Diet; Animal; liver cell transplantation; Digestive diseases
• ISSN: 1021-335X; 1791-2431
• DOI: 10.3892/or.17.1.55

In hepatocarcinogenesis-resistant DRH rats, preneoplastic hepatocytic lesions are smaller than those of usual rats during carcinogenesis. When preneoplastic hepatocytes from DRH and Donryu (original strain of DRH) were reciprocally transplanted into the livers of DRH and Donryu treated with 2-acetylaminofluorene (2-AAF) diet/two-thirds hepatectomy (PH), the Donryu cells formed small colonies within the DRH liver, whereas the DRH cells formed large colonies within the Donryu liver. The DRH liver showed less degree of oval cell proliferation after treatment with 2-AAF and PH, and DRH hepatocytes were more resistant to the growth-inhibitory effect of 2-AAF after PH. Furthermore, DRH hepatocytes were generally resistant to cytotoxicity of hepatotoxins. The tissue environment of the DRH liver, therefore, is less effective for selective growth of preneoplastic hepatocytes during the carcinogen treatment, which is probably a major cause of the hepatocarcinogenesis-resistance in DRH rats.