Antioxidant and antifungal activities of the flowers' essential oil of Tagetes minuta, (Z)-tagetone and thiotagetone

Herein, we describe our results on the determination of the chemical profile of the essential oil (EO) of flowers from Tagetes minuta L. grown in Southern Brazil. The major component of the EO is (Z)-tagetone 1 (70.64% w/w). Thiotagetone 6, a semi-synthetic derivative, was prepared from 1 in 82% yie...

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Bibliographic Details
Published inThe Journal of essential oil research Vol. 31; no. 2; pp. 160 - 169
Main Authors de Oliveira, Daniela Hartwig, Abib, Paola Bork, Giacomini, Rafaela Xavier, Lenardão, Eder João, Schiedeck, Gustavo, Wilhelm, Ethel A., Luchese, Cristiane, Savegnago, Lucielli, Jacob, Raquel Guimarães
Format Journal Article
LanguageEnglish
Published Taylor & Francis 04.03.2019
Subjects
(Z)-tagetone
antifungal
antioxidant
essential oil
Sphaceloma ampelinum
Tagetes minuta L
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Summary:Herein, we describe our results on the determination of the chemical profile of the essential oil (EO) of flowers from Tagetes minuta L. grown in Southern Brazil. The major component of the EO is (Z)-tagetone 1 (70.64% w/w). Thiotagetone 6, a semi-synthetic derivative, was prepared from 1 in 82% yield. Compounds 1 and 6 and the EO were evaluated for their antioxidant and antifungal activities in vitro. All the tested samples presented antioxidant effect in scavenging radical and in the lipid peroxidation assays. A good antifungal activity against Candida lipolityca, Candida parapsilosis, Trichosporon asahii and Sphaceloma ampelinum was observed. (Z)-Tagetone 1 inhibited the mycelia growth of S. ampelinum around 80% at 6 days. No acute toxicity (200 mg/kg) was observed in mice for the EO or the compounds 1 and 6. The lack of toxicity is an indicative for additional studies aiming their potential therapeutic use.
ISSN:1041-2905
2163-8152
DOI:10.1080/10412905.2018.1519465