Synthesis and biological activity of ferrocenyl furoyl derivatives

• Published in: Inorganic and nano-metal chemistry Vol. 47; no. 6; pp. 865 - 869
• Main Authors: Tombul, Mustafa, Bulut, Adnan, Türk, Mustafa, Uçar, Büşra, Işılar, Özer
• Format: Journal Article
• Language: English
• Published: Taylor & Francis 03.06.2017
• Subjects: biological activity; cytotoxicity; Ferrocene; furan; synthesis
• ISSN: 2470-1556; 2470-1564
• DOI: 10.1080/15533174.2016.1218510

Due to the fact that ferrocene and furan derivatives have long been known to be one of the most biologically active compounds, preparation of their new derivatives might serve a very important purpose. Herein, five furoyl ferrocenes were synthesized via E A S reaction utilizing AlCl 3 -EtAlCl 2 Lewis acids. The compounds 1-5 were obtained in moderate yields and characterized by IR, 1 H-NMR, 13 C-NMR, and mass spectrometry. Although toxicity increases with concentration, at 100 µg/mL concentration, the protection of cell viability was observed to be 70% level. At 50 µg/mL concentration, apoptosis in cancer cells observed was 63 ± 4% leading to high apoptosis ratio for the compound 3. For the compounds (1-5), the necrotic effects were found to be between 21% and 39% at 50 µg/mL concentration.