Automated O 2 titration improves exercise capacity in patients with hypercapnic chronic obstructive pulmonary disease: a randomised controlled cross-over trial

Automatically titrated O flows (FreeO ) was compared with constant O flow on exercise capacity, O saturation and risk of hyperoxia-related hypercapnia in patients with severe COPD with baseline hypercapnia and long-term oxygen therapy (LTOT). Twelve patients were enrolled in a randomised double-blin...

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Published inThorax Vol. 74; no. 3; pp. 298 - 301
Main Authors Vivodtzev, Isabelle, L'Her, Erwan, Vottero, Gabrielle, Yankoff, Claire, Tamisier, Renaud, Maltais, François, Lellouche, François, Pépin, Jean-Louis
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group 01.03.2019
Subjects
Life Sciences
exercise
copd ÀÜ mechanisms
ambulatory oxygen therapy
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Summary:Automatically titrated O flows (FreeO ) was compared with constant O flow on exercise capacity, O saturation and risk of hyperoxia-related hypercapnia in patients with severe COPD with baseline hypercapnia and long-term oxygen therapy (LTOT). Twelve patients were enrolled in a randomised double-blind cross-over study to perform exercise with either FreeO or constant flow. Endurance time (primary outcome) and SpO were both significantly improved with FreeO compared with constant flow (p<0.04), although pCO was similar in both conditions. Automated titration of O significantly and clinically improved endurance walking time in patients with severe COPD receiving LTOT, without worsening of pCO TRIAL REGISTRATION NUMBER: Results , NCT01575327.
ISSN:0040-6376
1468-3296
DOI:10.1136/thoraxjnl-2018-211967