Diagnostic value of miR-101 levels in blood and urine of patients with hypertensive disorder complicating pregnancy

• Published in: Clinical and experimental hypertension (1993) Vol. 44; no. 8; pp. 671 - 677
• Main Authors: Li, Yushan, Wei, Yuanyuan, Shao, Jiong
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 17.11.2022; Taylor & Francis Group
• Subjects: biomarkers; gestational hypertension; mild preeclampsia; miR-101; receiver operating characteristic curve; severe preeclampsia; severity of illness; sFlt-1; gestational hypertension; severity of illness; sFlt-1; biomarkers; miR-101; mild preeclampsia; receiver operating characteristic curve; severe preeclampsia
• ISSN: 1064-1963; 1525-6006
• DOI: 10.1080/10641963.2022.2110258

This study explored the miR-101 clinical significance in hypertensive disorder complicating pregnancy (HDCP). Pregnant women with gestational hypertension (GH)/mild preeclampsia (mPE)/severe preeclampsia (sPE) were included. The miR-101 levels were measured. Correlation between miR-101 and soluble fmslike tyrosine kinase-1 (sFlt-1), miR-101 predictive value, and factors influencing HDCP grade were evaluated. Serum miR-101 was down-regulated and negatively correlated with sFlt-1. miR-101 was an independent risk factor for HDCP and decreased with HDCP severity. The area under the curve of miR-101 in differentiating GH from mPE and mPE from sPE was 0.7764 and 0.8529. Serum miR-101 level may be a biomarker for grading HDCP.