Association between gene variants and the recurrence of atrial fibrillation: An updated meta-analysis

• Published in: Medicine (Baltimore) Vol. 98; no. 23; p. e15953
• Main Authors: Jiang, Tao, Wang, Ya-Nan, Qu, Qiang, Qi, Ting-Ting, Chen, Yun-Dai, Qu, Jian
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health 01.06.2019
• Subjects: Aged; Atrial Fibrillation - genetics; Chromosomes, Human - genetics; Female; Genetic Predisposition to Disease - genetics; Homeobox Protein PITX2; Homeodomain Proteins - genetics; Humans; Male; Middle Aged; Odds Ratio; Polymorphism, Single Nucleotide; Recurrence; Small-Conductance Calcium-Activated Potassium Channels - genetics; Systematic Review and Meta-Analysis; Transcription Factors - genetics
• ISSN: 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000015953

Studies showed the controversial results about the effect of common genetic polymorphisms on the atrial fibrillation (AF) recurrence. We performed the systematic review and meta-analysis to qualify the association between common genetic polymorphisms and AF recurrence. Articles were systematically retrieved PubMed, Web of Science, EMBASE, Wanfang, and CNKI database and 9 studies including 3204 patients were enrolled in our meta-analysis. Results showed that the associations were significant under rs2200733 3 genetic models (TT vs CC: odds ratio [OR] [confidence interval [CI]] = 1.336 [1.061-1.683], P = .014; CT vs CC: OR [CI] = 0.759 [0.614-0.937], P = .01; TT vs CT + CC: OR [CI] = 2.308 [1.440-3.700], P = .001). The association was significant under rs10033464 genetic model (TT vs GG: OR [CI] = 1.517 [1.165-1.976], P = .002). Rs13376333 on chromosome 1q21 (in KCNN3), rs7193343 and rs2106261 on chromosome 16q22 (in ZFHX3) were not associated with AF recurrence in our meta-analysis. In total, our meta-analysis found that rs2200733 and rs10033464 on chromosome 4q25 (near PITX2) were associated with the risk of AF recurrence.