Cytogenetic findings in 20 melanomas

We report cytogenetic studies performed on 20 patients with cutaneous malignant melanoma, characterized by clinical and histological parameters. Cytogenetic analyses were performed on peripheral blood lymphocytes, in order to exclude the presence of constitutional chromosomal aberrations, and on pri...

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Published inMelanoma research Vol. 3; no. 3; p. 169
Main Authors Grammatico, P, Catricalà, C, Potenza, C, Amantea, A, Roccella, M, Roccella, F, Eibenschutz, L, Del Porto, G
Format Journal Article
LanguageEnglish
Published England 01.06.1993
Subjects
Adult
Aged
Chromosome Aberrations
Female
Genetic Markers
Humans
Male
Melanoma - genetics
Melanoma - pathology
Middle Aged
Prognosis
Skin Neoplasms - genetics
Skin Neoplasms - pathology
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Summary:We report cytogenetic studies performed on 20 patients with cutaneous malignant melanoma, characterized by clinical and histological parameters. Cytogenetic analyses were performed on peripheral blood lymphocytes, in order to exclude the presence of constitutional chromosomal aberrations, and on primary cell cultures obtained from neoplastic skin lesions. A metastasis was also cultured in order to characterize chromosome markers. Specific markers found in more than one patient were t(1;14)(q21;q32) and aberrations of the 4q21,8q24 and 10q24q26 regions. The research aims to identify possible subtypes of melanomas related to specific chromosomal markers. It is hoped that this will contribute to understanding of the aetiology and evolution of the disease in order to obtain a more exact classification. We compare our results with the data reported in the literature and discuss the possible role of the cytogenetic analyses in human malignant melanoma.
ISSN:0960-8931
DOI:10.1097/00008390-199306000-00004