Clinical use of platelet-rich fibrin in the repair of non-healing incision wounds after fibular fracture surgery: A case report

• Published in: Medicine (Baltimore) Vol. 100; no. 50; p. e27994
• Main Authors: Lin, Xingzhen, Zhu, Manhua, Yuan, Juan, Zhi, Fang, Hou, XinJu
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 17.12.2021
• Subjects: Ankle Injuries - surgery; Ankle Joint; Bandages; Bone Transplantation; Clinical Case Report; Female; Fracture Fixation, Internal; Humans; Middle Aged; Platelet-Rich Fibrin; Platelet-Rich Plasma; Surgical Wound - therapy; Treatment Outcome; Wound Healing
• ISSN: 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000027994

This report describes rehabilitation for a 53-year-old female recovering from non-healing skin and soft tissue defect after distal tibial open fracture by using platelet-rich fibrin topical repair following an automobile accident. The patient was admitted to a rehabilitation specialty hospital approximately 1 year post a fracture of the distal left tibiofibula and separate surgical tibiofibular fracture incision and internal fixation + bone grafting. Clinical presentation included the left ankle incision was interrupted for about 3 cm with poor healing, a small amount of muscle necrosis, fat liquefaction, a large amount of yellow purulent secretion overflow and necrotic material was seen in the local wound. Platelet rich fibrin (PRF) gel was injected into the wounds and submerged sites to make full contact with the wounds and close the wounds with the autologous platelet-rich fibrin prepared by mixing, and then covered with oil gauze to keep the wounds moist and promote granulation growth. The outermost layer was covered with cotton pads. After 30 days of 2 PRF treatments, the skin defect was healed and no significant abnormality was observed at 6 months follow-up. Treatment with topical autologous platelet-rich plasma gel Significantly accelerates the healing of wounds, shortens healing time, improves healing quality and reduces scar formation without significant adverse effects.