Morphological Signatures of Neurogenesis and Neuronal Migration in Hypothalamic Vasopressinergic Magnocellular Nuclei of the Adult Rat

The arginine vasopressin (AVP)-magnocellular neurosecretory system (AVPMNS) in the hypothalamus plays a critical role in homeostatic regulation as well as in allostatic motivational behaviors. However, it remains unclear whether adult neurogenesis exists in the AVPMNS. By using immunoreaction agains...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of molecular sciences Vol. 25; no. 13; p. 6988
Main Authors Zhang, Limei, Zetter, Mario A, Hernández, Vito S, Hernández-Pérez, Oscar R, Jáuregui-Huerta, Fernando, Krabichler, Quirin, Grinevich, Valery
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 26.06.2024
Subjects
Animals
Arginine Vasopressin - metabolism
Blood vessels
Cell Movement
Cells
doublecortin (DCX)
Doublecortin Protein
Hypothalamus
Hypothalamus - cytology
Hypothalamus - metabolism
Male
microglia
Morphology
Neurogenesis
neurogenic niche
Neurons - cytology
Neurons - metabolism
Paraventricular Hypothalamic Nucleus - cytology
Paraventricular Hypothalamic Nucleus - metabolism
Physiology
radial glial cells
Rats
vasopressin
doublecortin (DCX)
vasopressin
neurogenic niche
Ki67
radial glial cells
microglia
BrdU
hypothalamus
Online AccessGet full text

Cover

More Information
Summary:The arginine vasopressin (AVP)-magnocellular neurosecretory system (AVPMNS) in the hypothalamus plays a critical role in homeostatic regulation as well as in allostatic motivational behaviors. However, it remains unclear whether adult neurogenesis exists in the AVPMNS. By using immunoreaction against AVP, neurophysin II, glial fibrillar acidic protein (GFAP), cell division marker (Ki67), migrating neuroblast markers (doublecortin, DCX), microglial marker (Ionized calcium binding adaptor molecule 1, Iba1), and 5'-bromo-2'-deoxyuridine (BrdU), we report morphological evidence that low-rate neurogenesis and migration occur in adult AVPMNS in the rat hypothalamus. Tangential AVP/GFAP migration routes and AVP/DCX neuronal chains as well as ascending AVP axonal scaffolds were observed. Chronic water deprivation significantly increased the BrdU+ nuclei within both the supraaoptic (SON) and paraventricular (PVN) nuclei. These findings raise new questions about AVPMNS's potential hormonal role for brain physiological adaptation across the lifespan, with possible involvement in coping with homeostatic adversities.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25136988