5,5′-(Piperazine-1,4-diyl)bis(4-chloro-3H-1,2-dithiol-3-one)

Conjugates of 3H-1,2-dithiol-3-ones with various biologically active compounds are intensively investigated. Although many derivatives of this class have been described in the literature, the compounds containing two dithiole cycles have been explored much less. In this communication, it was shown t...

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Bibliographic Details
Published inMolBank Vol. 2022; no. 3; p. M1411
Main Authors Ogurtsov, Vladimir A., Rakitin, Oleg A.
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.09.2022
Subjects
3H-1,2-Dithiole-3-ones
5,5′-(piperazine-1,4-diyl)bis(4-chloro-3H-1,2-dithiol-3-one)
Cancer
Chemical analysis
Conflicts of interest
Infrared spectroscopy
NMR
Nuclear magnetic resonance
nucleophilic substitution
piperazine
Scientific imaging
Solvents
Spectrometry
United States > US
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Summary:Conjugates of 3H-1,2-dithiol-3-ones with various biologically active compounds are intensively investigated. Although many derivatives of this class have been described in the literature, the compounds containing two dithiole cycles have been explored much less. In this communication, it was shown that the reaction of 4,5-dichloro-3H-1,2-dithiol-3-one with piperazine can selectively lead to the mono-product, 4-chloro-5-piperazin-1-yl-3H-1,2-dithiol-3-one and bis-product, 5,5′-(piperazine-1,4-diyl)bis(4-chloro-3H-1,2-dithiol-3-one). The structure of the synthesized compounds was established by elemental analysis, high resolution mass-spectrometry, 1H, 13C NMR and IR spectroscopy, and mass-spectrometry.
ISSN:1422-8599
1422-8599
DOI:10.3390/M1411