Continuous monitoring of the partial pressure of oxygen in cerebral venous blood

• Published in: Neurosurgery Vol. 41; no. 2; p. 462
• Main Authors: Rieger, A, Menzel, M, Rainov, N G, Sanchin, L, Rot, S, Furka, I, Görömbey, Z, Burkert, W
• Format: Journal Article
• Language: English
• Published: United States 01.08.1997
• Subjects: Animals; Blood Gas Analysis; Blood Pressure; Cerebral Veins; Cerebrovascular Circulation; Intracranial Pressure; Monitoring, Physiologic; Oxygen - blood; Partial Pressure; Polarography; Swine
• ISSN: 0148-396X
• DOI: 10.1097/00006123-199708000-00027

Clinical oxygen monitoring in the injured brain is somewhat difficult. However, ischemia is one of the major factors responsible for secondary tissue damage after head injury or subarachnoid hemorrhage. Therefore, the aim of the present study was to investigate the value of continuously monitoring the partial pressure of oxygen in cerebral venous blood (PcvO2) during changes in intracranial pressure (ICP). In eight domestic pigs with Clark type probes placed in the posterior third of the superior sagittal sinus, PcvO2 was continuously registered while ICP was stepwise elevated by an inflatable balloon placed below the tentorium. Arterial blood pressure was continuously monitored, cerebral perfusion pressure (CPP) was calculated, and arterial partial carbon dioxide pressure and partial pressure of oxygen were registered intermittently. The mean intraparenchymal ICP before the start of balloon inflation was 5 +/- 1 mm Hg, the mean CPP was 80 +/- 15 mm Hg, and the mean PcvO2 was 36 +/- 3 mm Hg. At maximum ICP elevation, CPP decreased to 20 +/- 12 mm Hg, PcvO2 decreased to 10 +/- 6 mm Hg, and ICP increased to 90 +/- 10 mm Hg. Strong linear correlations between ICP and PcvO2 and between CPP and PcvO2 were revealed, and mean correlation coefficients of 0.89 for ICP/PcvO2 and 0.73 for CPP/PcvO2 were calculated. The present study demonstrates that polarographic PcvO2 monitoring in the superior sagittal sinus is a reliable method for the early detection of reduced CPP during ICP elevation. This technique is capable of registering the global oxygen supply and oxygen consumption of the brain. It seems superior to jugular venous oxymetry and is better suited for clinical use because of a somewhat low artifact susceptibility.