IgA Vasculitis Associated With COVID-19

IgA vasculitis, also known as Henoch-Schonlein Purpura (HSP), is an inflammatory disorder of small blood vessels that can present with palpable purpura, arthralgias, abdominal pain, and kidney disease. It is most commonly found in pediatric patients after an inciting infection but has been seen acro...

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Bibliographic Details
Published inCurēus (Palo Alto, CA) Vol. 15; no. 5; p. e38725
Main Authors Salem, Yousef, Alam, Zaryab, Shalabi, Mojahed M, Hosler, Gregory A, Acharya, Sampada
Format Journal Article
LanguageEnglish
Published United States Cureus Inc 08.05.2023
Cureus
Subjects
Biopsy
Case reports
COVID-19
Creatinine
Dermatology
Disease transmission
Infectious Disease
Metabolism
Patients
Pediatrics
Proteins
Rheumatology
Steroids
Urinalysis
Viral infections
Fort Worth Texas
United States > US
dermatopathology
covid-19
henoch-schonlein purpura
iga vasculitis
vasculitis
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Summary:IgA vasculitis, also known as Henoch-Schonlein Purpura (HSP), is an inflammatory disorder of small blood vessels that can present with palpable purpura, arthralgias, abdominal pain, and kidney disease. It is most commonly found in pediatric patients after an inciting infection but has been seen across all ages and associated with certain drugs and vaccines. COVID-19 has been associated with various cutaneous manifestations, but HSP is a rarely reported one. We present a case of a 21-year-old female presenting with a petechial rash found to be seronegative IgA vasculitis presenting concurrently with dyspnea secondary to COVID-19. She was initially seen by an outside practitioner, tested negative for COVID, and was prescribed a course of oral prednisone. Shortly thereafter, she visited the ED for worsening shortness of breath and tested positive for COVID-19, for which she received Paxlovid. Biopsy after a visit to a dermatologist confirmed intramural IgA deposition on immunofluorescence, and she was tapered off prednisone and started on azathioprine.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.38725