Splenic rupture as a cause of sudden death in undiagnosed chronic myelogenous leukemia

A 35-year-old man died suddenly in a clinic waiting area after repeated visits for flu-like symptoms. At autopsy, hemoperitoneum, splenic capsular rupture, and splenomegaly were found. Microscopic examination, special stains, and immunoperoxidase studies revealed findings consistent with chronic mye...

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Bibliographic Details
Published inThe American journal of forensic medicine and pathology Vol. 9; no. 3; p. 241
Main Authors Nestok, B R, Goldstein, J D, Lipkovic, P
Format Journal Article
LanguageEnglish
Published United States 01.09.1988
Subjects
Adult
Death, Sudden - etiology
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - complications
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology
Male
Rupture, Spontaneous
Splenic Rupture - etiology
Splenic Rupture - pathology
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Summary:A 35-year-old man died suddenly in a clinic waiting area after repeated visits for flu-like symptoms. At autopsy, hemoperitoneum, splenic capsular rupture, and splenomegaly were found. Microscopic examination, special stains, and immunoperoxidase studies revealed findings consistent with chronic myelogenous leukemia. Spontaneous splenic rupture is an unusual presenting feature of chronic myelogenous leukemia. The symptoms of leukemia may mimic those of other "benign" disorders and misdiagnosis may lead to catastrophic consequences in some instances.
ISSN:0195-7910
DOI:10.1097/00000433-198809000-00014