Tardive dyskinesia as a result of long-term prochlorperazine use

Prochlorperazine is a centrally acting dopamine receptor antagonist that is most commonly used for the treatment of nausea and vomiting. Like many dopamine antagonists, prochlorperazine has the ability to induce extrapyramidal reactions in susceptible patients. Rarely, however, have cases of tardive...

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Bibliographic Details
Published inSouthern medical journal (Birmingham, Ala.) Vol. 89; no. 10; pp. 989 - 991
Main Authors Alberts, V A, Catalano, G, Poole, M A
Format Journal Article
LanguageEnglish
Published United States 01.10.1996
Subjects
Antiemetics - adverse effects
Dopamine Antagonists - adverse effects
Dyskinesia, Drug-Induced - etiology
Fatal Outcome
Female
Granisetron - therapeutic use
Humans
Middle Aged
Nausea - drug therapy
Ondansetron - therapeutic use
Prochlorperazine - adverse effects
Time Factors
Vomiting - drug therapy
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Summary:Prochlorperazine is a centrally acting dopamine receptor antagonist that is most commonly used for the treatment of nausea and vomiting. Like many dopamine antagonists, prochlorperazine has the ability to induce extrapyramidal reactions in susceptible patients. Rarely, however, have cases of tardive dyskinesia been caused by the long-term use of this agent. We report the case of a patient who used prochlorperazine for a prolonged period and, during hospital admission, was found to have a new movement disorder. Alternative antiemetics that do not pose a risk of movement disorders, such as ondansetron and granisetron, are readily available and are efficacious.
ISSN:0038-4348
DOI:10.1097/00007611-199610000-00010