Nuts and bolts of salivary gland pathology in primary Sjögren's syndrome

Primary Sjögren's syndrome (pSS) is a chronic, systemic, inflammatory autoimmune disease characterised by lymphocyte proliferation and progressive damage to exocrine glands. Salivary gland histopathology based on salivary gland biopsy is relevant for the diagnosis of pSS and therefore broadly a...

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Bibliographic Details
Published inClinical and experimental rheumatology Vol. 41; no. 12; p. 2525
Main Authors Zabotti, Alen, Giovannini, Ivan, Longhino, Simone, Manfrè, Valeria, Rizzo, Maria Teresa, De Vita, Salvatore, Di Loreto, Carla, Quartuccio, Luca, Pegolo, Enrico
Format Journal Article
LanguageEnglish
Published Italy 01.12.2023
Subjects
Biopsy
Humans
Lymphoma - pathology
Parotid Gland - diagnostic imaging
Parotid Gland - pathology
Salivary Glands
Salivary Glands, Minor - pathology
Sjogren's Syndrome
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Summary:Primary Sjögren's syndrome (pSS) is a chronic, systemic, inflammatory autoimmune disease characterised by lymphocyte proliferation and progressive damage to exocrine glands. Salivary gland histopathology based on salivary gland biopsy is relevant for the diagnosis of pSS and therefore broadly applied in clinical practice. Tissue can be obtained from labial salivary glands (LSG) biopsy or from major salivary glands (MSG) biopsy, namely the parotid; in this latter scenario, the procedure can be either an open surgical biopsy or a US guided core needle biopsy.In this review we will: i) present the histopathological findings that may be encountered by pathologists on biopsies from pSS patients; ii) discuss the advantages and disadvantages of the surgical and/or imaging guided procedures to obtain tissues from LSG or MSG; iii) describe the histopathological features of lymphoma of MSG in pSS patients.
ISSN:0392-856X
1593-098X
DOI:10.55563/clinexprheumatol/fcjoqx