Primary Pancreatic Lymphoma: Endosonography-Guided Tissue Acquisition Diagnosis

Primary pancreatic lymphoma is a rare type of cancer, that accounts for 0.1-0.5% of lymphomas and about 0.2% of all primary pancreatic tumors. Diffuse Large B-cell Lymphoma is the most common subtype. The diagnosis is possible if the lymphoma is located in the pancreas, but the differential diagnosi...

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Published inCurēus (Palo Alto, CA) Vol. 15; no. 2; p. e34936
Main Authors Orsini-Arman, Anna Carolina, Surjan, Rodrigo Cañada T, Venco, Filadélfio E, Ardengh, José C
Format Journal Article
LanguageEnglish
Published United States Cureus Inc 13.02.2023
Cureus
Subjects
Abdomen
Bile ducts
Chemotherapy
Endoscopy
Gastroenterology
Hematology
Histology
Hospitals
Laboratories
Lymphatic system
Lymphoma
Medical diagnosis
Oncology
Pancreas
Pancreatic cancer
Remission (Medicine)
Tomography
Tumors
Ultrasonic imaging
Veins & arteries
United States > US
diagnosis
fine needle biopsy
endoscopic ultrasound
imunohistochemistry
lymphoma pancreatic
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Summary:Primary pancreatic lymphoma is a rare type of cancer, that accounts for 0.1-0.5% of lymphomas and about 0.2% of all primary pancreatic tumors. Diffuse Large B-cell Lymphoma is the most common subtype. The diagnosis is possible if the lymphoma is located in the pancreas, but the differential diagnosis with pancreatic ductal adenocarcinoma is difficult. The diagnostic accuracy of endosonography-guided fine needle aspiration is inadequate, and thus it is common to diagnose these masses only after surgical resection. The endosonography-guided tissue acquisition allows greater accuracy in the pancreatic masses, as it determines optimal access to histological analysis using tissue in paraffin blocks for complementary immunohistochemical, and molecular tests. Thus, this elaborate diagnostic environment allows the adoption of appropriate treatment strategies for patients with this condition. The authors describe four cases of primary pancreatic lymphoma indicated for surgical resection due to suspected pancreatic cancer, with the diagnosis of Diffuse Large B-cell Lymphoma obtained by endosonography-guided tissue acquisition, changing the therapeutic strategy through the adoption of adequate chemotherapy treatment with good progress.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.34936