Myelodysplastic syndrome: identification in the routine hematology laboratory

The Coulter S+IV electronically generates an automated white blood cell differential which counts 10,000+ cells per sample, separating lymphocytes, mononuclear cells, and granulocytes. In patients with preleukemic or so-called myelodysplastic syndromes, the histograms are consistently abnormal. CBCs...

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Bibliographic Details
Published inSouthern medical journal (Birmingham, Ala.) Vol. 80; no. 8; p. 969
Main Authors Rappaport, E S, Helbert, B, Ladd, D J, Trowbridge, A A
Format Journal Article
LanguageEnglish
Published United States 01.08.1987
Subjects
Adult
Aged
Aged, 80 and over
Blood Cell Count - instrumentation
Bone Marrow Examination
Erythrocyte Count - instrumentation
Evaluation Studies as Topic
Female
Humans
Leukocyte Count - instrumentation
Male
Myelodysplastic Syndromes - diagnosis
Platelet Count - instrumentation
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Summary:The Coulter S+IV electronically generates an automated white blood cell differential which counts 10,000+ cells per sample, separating lymphocytes, mononuclear cells, and granulocytes. In patients with preleukemic or so-called myelodysplastic syndromes, the histograms are consistently abnormal. CBCs of five patients demonstrate the variable features of myelodysplasia involving abnormal monocytosis, neutropenia, thrombocytopenia, and macro-ovalocytic anemias. The histogram analysis of white blood cells is a rapid, economic way of alerting the hematologist to a possible diagnostic problem in the elderly patient population.
ISSN:0038-4348
DOI:10.1097/00007611-198708000-00009