Systemic lupus erythematosus diagnosed during interferon alfa therapy

We describe a patient who had clinical manifestations of several autoimmune disorders: Sjögren's syndrome, benign hypergammaglobulinemic purpura of Waldenström, and systemic lupus erythematosus (SLE). The SLE was diagnosed during therapy with interferon alfa. Testing for anti-Ro and anti-La ant...

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Bibliographic Details
Published inSouthern medical journal (Birmingham, Ala.) Vol. 89; no. 8; pp. 810 - 814
Main Authors Morris, L F, Lemak, N A, Arnett, Jr, F C, Jordon, R E, Duvic, M
Format Journal Article
LanguageEnglish
Published United States 01.08.1996
Subjects
Female
Humans
Hypergammaglobulinemia - etiology
Interferon-alpha - adverse effects
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - diagnosis
Male
Middle Aged
Purpura - etiology
Sjogren's Syndrome - drug therapy
Sjogren's Syndrome - etiology
Waldenstrom Macroglobulinemia - etiology
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Summary:We describe a patient who had clinical manifestations of several autoimmune disorders: Sjögren's syndrome, benign hypergammaglobulinemic purpura of Waldenström, and systemic lupus erythematosus (SLE). The SLE was diagnosed during therapy with interferon alfa. Testing for anti-Ro and anti-La antibodies was negative until the serum was diluted to eliminate a possible prozone phenomenon of antibody excess.
Bibliography:ObjectType-Case Study-3
SourceType-Scholarly Journals-1
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ISSN:0038-4348
DOI:10.1097/00007611-199608000-00012