Histologic and histochemical investigation of Gaucher cells

Electron microscopic investigations suggest that morphologically, Gaucher cells and histiocytes are very similar. The fact that there are tubular elements in the lysosomes strongly suggests the possibility of lysosomes as the precursors of Gaucher bodies. By means of the lectin staining methods, the...

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Bibliographic Details
Published inClinical orthopaedics and related research no. 166; p. 233
Main Authors Matsubara, T, Yoshiya, S, Maeda, M, Shiba, R, Hirohata, K
Format Journal Article
LanguageEnglish
Published United States 01.06.1982
Subjects
Biopsy
Diagnosis, Differential
Femur - pathology
Femur Head Necrosis - etiology
Gaucher Disease - complications
Gaucher Disease - diagnosis
Gaucher Disease - pathology
Glucosylceramides - analysis
Histocytochemistry
Humans
Leukodystrophy, Globoid Cell - diagnosis
Microscopy, Electron
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Summary:Electron microscopic investigations suggest that morphologically, Gaucher cells and histiocytes are very similar. The fact that there are tubular elements in the lysosomes strongly suggests the possibility of lysosomes as the precursors of Gaucher bodies. By means of the lectin staining methods, the localization of glucocerebroside is clearly demonstrable in Gaucher cells. Lectin staining is the significant diagnostic feature of both Gaucher's and Krabbe's diseases.
ISSN:0009-921X
DOI:10.1097/00003086-198206000-00040