Influence of age and smoking on drug kinetics in man: studies using model compounds

The effect of advanced age on drug disposition and response is the subject of an increasing number of research studies. Cigarette smoking and other environmental factors have been shown to influence the metabolism of some drugs. Studies of the effect of age on the pharmacokinetics of antipyrine, ind...

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Bibliographic Details
Published inClinical pharmacokinetics Vol. 5; no. 4; p. 309
Main Authors Vestal, R E, Wood, A J
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1980
Subjects
Adolescent
Adult
Aged
Aging
Antipyrine - metabolism
Humans
Indocyanine Green - metabolism
Kinetics
Liver - blood supply
Middle Aged
Pharmaceutical Preparations - metabolism
Propranolol - metabolism
Regional Blood Flow
Smoking
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Summary:The effect of advanced age on drug disposition and response is the subject of an increasing number of research studies. Cigarette smoking and other environmental factors have been shown to influence the metabolism of some drugs. Studies of the effect of age on the pharmacokinetics of antipyrine, indocyanine green and propranolol indicate that the association of increased drug metabolism and smoking occurs predominantly in the young and that apparent liver blood flow declines with age regardless of smoking habits. This age related effect of smoking on drug metabolism may reflect a reduced capacity for hepatic enzyme induction in the elderly. The relative importance of age related alterations in the intrinsic drug metabolising ability of the liver and in liver blood flow depend on the pharmacokinetic characteristics of the drug being investigated.
ISSN:0312-5963
DOI:10.2165/00003088-198005040-00001